Education

1998, B.S., Biochemistry, Xiamen University;

2003, Ph.D.,  Biochemistry&Molecular Biology/Zoology, Xiamen University.

Professional Experience

2003, Lecturer, School of Life Sciences, Xiamen University;

2006, Associate Professor, School of Life Sciences, Xiamen University;

2011, Professor, School of Life Sciences, Xiamen University.

Research Area

Research and development of recombinant human vaccine;

Structural basis and functional implication for underlying immune epitopes of key infectious viruses;

Structure-based molecular simulation and rational design for vaccine.

Selected Publications

1. Tang X, Yang C, Gu Y, Song C, Zhang X, Wang Y, Zhang J, Hew CL, Li S*, Xia N*, Sivaraman J*. Structural basis for the neutralization and genotype specificity of hepatitis E virus. ProcNatl Acad Sci U S A. 2011 Jun 21;108(25): 10266-71.Epub 2011 Jun 3.

2. Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, Du H, Shih JW, Hew CL, Sivaraman J*, Xia N*. Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction. PLoS Pathog. 2009 Aug;5(8): e1000537. Epub 2009 Aug 7.

3. Li S, Zhang J, He Z, Gu Y, Liu R, Lin J, Chen Y, Ng M, Xia N*. Mutational analysis of essential interactions involved in the assembly of hepatitis E virus capsid. J Biol Chem. 2005 Feb 4;280(5): 3400-6. Epub 2004 Nov 22.

4. Li S, Zhang J, Li Y, Ou S, Huang G, He Z, Ge S, Xian Y, Pang S, Ng M, Xia N*. A bacterially expressed particulate hepatitis E vaccine: antigenicity, immunogenicity and protectivity on primates. Vaccine. 2005 Apr 22;23(22): 2893-2901.

5. Gu Y, Cao F, Wang L, Hou W, Zhang J, Hew CL, Li S*,Yuan YA*, Xia N*. Structure of a Novel Shoulder-to-Shoulder p24 Dimer in Complex with the Broad-Spectrum Antibody A10F9 and Its Implication in Capsid Assembly. PLoS One. 2013 Apr 19;8(4): e61314.

6. Yang C, Pan H, Wei M, Zhang X, Wang N, Gu Y, Du H, Zhang J, Li S*, Xia N*. Hepatitis E virus capsid protein assembles in 4M urea in the presence of salts. Protein Sci. 2013 Mar;22(3): 314-26.

7. Yu H, Li S*, Yang C, Wei M, Song C, Zheng Z, Gu Y, Du H, Zhang J, Xia N. Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78. J Mol Model. 2011 May;17(5): 987-95. Epub 2010 Jul 14.

8. Yang K, Li S*, He F, Zhang J, Wei M, Pan H, Yang C, Xiong J, Zhang J, Xia N. Expression and Purification of Soluble HIV-1 Envelope Glycoprotein gp160 Mutant from Saccharomyces Cerevisiae. J Biosci Bioeng. 2009 Jul;108(1): 5-10.

9. Yan Y, Li S*, Yang C, Luo W, Wang M, Chen Y, Luo H, Wu T, Zhang J,Xia N. Prediction of a common neutralizing epitope of H5N1 avian influenza virus by in silico molecular docking. Chinese Science Bulletin. 2008.53(1).