Shu-Hai LIN, Ph.D.

Professor

E-mail: shuhai@xmu.edu.cn

Education

2003, BSc, College of Chinese Medicine, Guangzhou University of Chinese Medicine

2005, MSc, School of Pharmaceutical Sciences, Sun Yat-sen University

2011, Ph. D., Department of Chemistry, Hong Kong Baptist University

Professional Experience

2006-2007, PepTech (Shanghai) Pharmaceutical Co., Ltd.

2011-2012, Postdoctoral Fellow, Department of Chemistry, Hong Kong Baptist University

2012-2014, Research Assistant Professor, Department of Chemistry, Hong Kong Baptist University

2014-2015, Senior Research Associate, School of Chinese Medicine, Hong Kong Baptist University

Dec. 2015-Jan. 2018, Associate Professor, Professor, College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine

Feb. 2018-Aug. 2018, Professor, Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Oct. 2018-Professor, School of Life Sciences, Xiamen University

Research Area

Metabolomics: By employing state-of-the-art mass spectrometry and stable isotope (13C, 15N, 2H) atoms in the tracer molecules, we analyze the specific metabolic pathways. Based on mass isotopologue distribution, we will establish mathematical modeling to delineate the activity and dynamic changes of metabolic pathways for metabolic flux analysis in in vivo and vitro. In vivo, we mainly focus on metabolic cross-talks between tissues and circulation system; in vitro, we mainly focus on metabolic communications between immune cells and other types of cells as well as metabolic shuttling at subcellular level, such as malate-aspartate shuttle, citrate-pyruvate shuttle and glycerophosphate shuttle.

Cellular metabolism: In the past decades, the impacts of microenvironment on cancer metabolism are largely overlooked. By applying metabolic flux analysis in vivo, in combination with biochemistry and genetics, we will quantitatively explain the impact of environmental factors on metabolic reprogramming in tumors. In particular, we are developing novel mass spectrometric technologies and collaborating with oncologists and immunologists for a better understanding of precision modulation of immunometabolism within the tumor microenvironment. We are also interested in the research fields ranging from distribution of nutrient utilization and energy expenditure in metabolic biology to metabolomics of clinical cohorts in precision medicine.

Selected Publications

[1] Cao Y#, Lin SH#, Wang Y, Chin YE, Kang L, Mi J. Glutamic pyruvate transaminase GPT2 promotes tumorigenesis of breast cancer cells by activating sonic hedgehog signaling. Theranostics. 2017; 7(12): 3021-3033.

[2] Chen GQ, Gong RH, Yang DJ, Zhang G, Lu AP, Yan SC, Lin SH*, Bian ZX*. Halofuginone Dually Regulates Autophagic Flux through Nutrient-Sensing Pathways in Colorectal Cancer. Cell Death Dis., 2017; 8(5): e2789.

[3] Cao TT#, Lin SH#, Fu L#, Tang Z, Che CM, Zhang LY, Ming XY, Liu TF, Tang XM, Tan BB, Xiang D, Li F, Chan OY, Xie D, Cai Z, Guan XY. Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells. Carcinogenesis. 2017; 38(1): 94-104.

[4] Gao X#, Lin SH#, Ren F, Li JT, Chen JJ, Yao CB, Yang HB, Jiang SX, Yan GQ, Wang D, Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang PY, Lei QY. Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016; 7: 11960.

[5] Lin SH#, Liu T#, Ming X, Tang Z, Fu L, Schmitt-Kopplin P, Kanawati B, Guan XY, Cai Z. Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions. Sci. Rep. 2016; 6: 21184.

[6] Chen GQ, Tang CF, Shi XK, Lin CY, Fatima S, Pan XH, Yang DJ, Zhang G, Lu AP, Lin SH*, Bian ZX*. Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism. Oncotarget. 2015; 6(27): 24148-62.

[7] Tang Z, Li S, Guan X, Schmitt-Kopplin P, Lin S*, Cai Z*. Rapid assessment of coenzyme Q10 redox state using ultrahigh performance liquid chromatography tandem mass spectrometry. Analyst. 2014; 139(21): 5600-4.

[8] Lin S#, Kanawati B#, Liu L, Witting M, Li M, Huang J, Schmitt-Kopplin P, Cai Z. Ultrahigh resolution mass spectrometry-based metabolic characterization reveals cerebellum as a disturbed region in two animal models. Talanta. 2014; 118(1): 45-53.

[9] Lin S, Liu H, Kanawati B, Liu L, Dong J, Li M, Huang J, Schmitt-Kopplin P, Cai Z. Hippocampal metabolomics using ultrahigh-resolution mass spectrometry reveals neuroinflammation from Alzheimer's disease in CRND8 mice. Anal. Bioanal. Chem. 2013; 405(15): 5105-17.

[10] Lin S, Yang Z, Liu H, Tang L, Cai Z. Beyond glucose: Metabolic shifts in responses to the effects of the oral glucose tolerance test and the high-fructose diet in rats. Mol. Biosyst. 2011; 7(5): 1537-48.

[11] Lin S, Yang Z, Liu H, Cai Z. Metabolomic Analysis of Liver and Skeletal Muscle Tissues in C57BL/6J and DBA/2J Mice Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Mol. Biosyst.2011; 7(6): 1956-65.

[12] Lin S, Yang Z, Zhang X, Bian Z, Cai Z. Hippocampal Metabolomics Reveals 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Toxicity Associated with Ageing in Sprague-Dawley Rats. Talanta, 2011; 85(2): 1007-12.

[13] Lin S, Chan W, and Cai Z. Liquid chromatography/mass spectrometry for investigating the biochemical effects induced by aristolochic acid in rats: the plasma metabolome. Rapid Commnun. Mass Spectrom. 2010; 24(9): 1312-8.

[14] Lin S, Liu N, Yang Z, Song W, Wang P, Chen H, Lucio M, Schmitt-Kopplin P, Chen G, Cai Z. GC/MS-based metabolomics reveals fatty acid biosynthesis and cholesterol metabolism in cell lines infected with influenza A virus. Talanta. 2010; 83(1): 262-8.

[15] Lin S, Wang D, Yang D, Yao J, Tong Y, Chen J. Characterization of steroidal saponins in crude extract from Dioscoreanipponica Makino by liquid chromatography tandem multi-stage mass spectrometry. Anal Chim Acta. 2007; 599(1): 98-106.