Weijia WANG, Ph.D.
Associate Professor
Nuclear receptor and Cellular stress
E-mail: wangwj@xmu.edu.cn
Education
2005-2009, School of Life Sciences, Xiamen University, Bachelor;
2006-2015, School of Life Sciences, Xiamen University, Ph.D.;
Professional Experience
2015-2017, School of Medicine, Yale University, Postdoc Fellow;
2017-2019, Perelman School of Medicine, University of Pennsylvania, Postdoc Fellow;
2019-present, School of Life Sciences, Xiamen University, Associate Professor.
Research Area
1. The main interest is the understanding of the biological effects of nuclear receptors, focusing on the regulatory roles of nuclear receptors in anti-tumor process and screening small molecular compounds targeting to nuclear receptors.
2. We are also interested in investigating cellular stress under physiological or pathological condition, focusing mitochondrial dependent cell death.
Selected Publications (*Corresponding author # co-first author)
1. Xiao Q#, Wu JB#, Wang WJ#, Zheng YX, Chang WC, Yu XQ, Meeth K, Sahraei M, Bothwel ALM, Chen LP, Bosenberg M, Li L*, Tang WW* and Wu DQ*. DKK2 imparts tumor immunity evasion through LRP5-mediated suppression of STAT5 signaling and cytotoxic immune cell activation, Nature Medicine. 2018, 24,3,262-270.
2. He JP#, Hou PP#, Chen QT#, Wang WJ, Sun XY, Yang PB, Li YP, Yao LM, Li X, Jiang XD, Chien KY, Zhang ZM, Wu QW, Cowin AJ, Wu Q, Chen HZ*. Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression. Cancer Research. 2018, 78(17):4853-4864.
3. Bian XL#, Chen HZ#, Yang PB#, Li YP#, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q*. Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nature Communications. 2017.8:14420
4. Wang WJ#, Wang Y#, Hou PP#, Li FW#, Zhou B, Chen HZ, Bian XL, Cai QX, Xing YZ, He JP, Zhang HK, Huang PQ, Lin TW * and Wu Q *. Autophagic death in cancer cells by agonizing TR3 and attenuating Akt2 activity. Chemistry & Biology (renamed as Cell Chemical Biology), 2015; 22(8): 1040-1051.
5. Li L#, Liu Y#, Chen HZ#, Li FW#, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T*, Wu Q*. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nature Chemical Biology. 2015, 11(5):339-46.
6. Wang WJ#, Wang Y#, Chen HZ#, Xing YZ#, Li FW#, Zhang Q, Zhou B, Zhang HK, Zhang J, Bian XL, Li L, Liu Y, Zhao BX, Chen Y, Wu R, Li AZ, Yao LM, Chen P, Zhang Y, Tian XY, Beermann Friedrich, Wu M, Han J, Huang PQ, Lin T*, Wu Q*. Orphan nuclear receptor TR3 acts in autophagic cell death of melanoma via a mitochondrial signaling pathway. Nature Chemical Biology. 2014, 10:133-140.
7. Chen HZ*#, Wen Q#, Wang WJ, He JP, Wu Q. The orphan nuclear receptor TR3/Nur77 regulates ER stress and induces apoptosis via interaction with TRAPγ. The International Journal of Biochemistry & Cell Biology, 2013, 45:1600 – 1609.
8. Wang RH#, He JP#, Su ML#, Luo J#, Xu M, Du XD, Chen, HZ, Wang WJ, Wang Y, Zhang N, Zhao BX, Zhao WX, Shan ZG, Han JH, Chang CS, Wu Q*. The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signaling. EMBO Molecular Medicine. 2013; 1(5), 137-148.
9. Chen HZ, Li L, Wang WJ, Du XD, Wen Q, He JP, Zhao BX, Li GD, Zhou W, Xia Y, Yang QY, Hew C-L, Liou Y-C*, Wu Q*. Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis. Oncogene. 2012, 31：2876-2887.
10. Chen HZ#, Liu QF#, Li L#, Wang WJ, Yao LM, Yang M, Liu B, Chen Wei, Zhan YY, Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA*, Wu Q*. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signaling. Gut. 2012, 61：714-724.
11. Zhan YY#, Chen Y#, Zhang Q#, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi CF, Yang K, Li AZ, Xin YZ, Li Y, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang CS, Huang PQ, Lin TW* and Wu Q*. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nature Chemical Biology. 2012; 11(8), 897-904.
