Education

2000, B.Sc., Biochemistry, Xiamen University;

2006, Ph.D., Biochemistry & Molecular Biology/Cell Biology, Xiamen University.

Professional Experience

2006, Assistant Professor, School of Life Sciences, Xiamen University;

2013, Associate Professor, School of Life Sciences, Xiamen University.

Research Area

Antiviral monoclonal antibody generation: based on functional screening by virus-infection cell model, recombinant antigen reactivity and et. al, centering the interest on HIV neutralizing monoclonal antibody, esp. recognizing wide-spectrum and/or immunodominant regions.

Virus antigen investigation associated with key epitopes: preparation of antigen or particulate antigen harbouring interest functional epitope.

Selected Publications

1. Hou W¹, Fang C1, Liu J, Yu H, Qi J, Zhang X, Yuan R, Xiong D, Gao S, Adam Yuan Y, Li S, Gu Y*, Xia N. Molecular insights into the inhibition of HIV-1 infection using a CD4 domain-1-specific monoclonal antibody. Antiviral Res. 2015 Aug 8. pii: S0166-3542(15)00190-4.

2. Gu Y¹, Tang X¹, Zhang X, Song C, Zheng M, Wang K, Zhang J, Ng MH, Hew CL, Li S*, Xia N*, Sivaraman J*. Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody. Cell Res. 2015 May;25(5):604-20. (co-1st)

3. Wang D, Li Z, Xiao J, Wang J, Zhang L, Liu Y, Fan F, Xin L, Wei M, Kong Z, Yu H, Gu Y, Zhang J, Li S, Xia N. Identification of Broad-Genotype HPV L2 Neutralization Site for Pan-HPV Vaccine Development by a Cross-Neutralizing Antibody. PLoS One. 2015 Apr 23;10(4):e0123944.

4. Gu Y, Cao F, Wang L, Hou W, Zhang J, Hew CL, Li S*, Yuan YA*, Xia N*. Structure of a Novel Shoulder-to-Shoulder p24 Dimer in Complex with the Broad-Spectrum Antibody A10F9 and Its Implication in Capsid Assembly. PLoS One. 2013 Apr 19;8(4):e61314.

5. Yang C, Pan H, Wei M, Zhang X, Wang N, Gu Y, Du H, Zhang J, Li S*, Xia N*.Hepatitis E virus capsid protein assembles in 4M urea in the presence of salts. Protein Sci. 2013 Mar;22(3):314-26.

6. Gu Y, Hou W, Xu C, Li S, Shih JW, Xia N*. The enhancement of RNAi against HIV in vitro and in vivo using H-2K(k) protein as a sorting method. J Virol Methods. 2012 Jun;182(1-2):9-17.

7. Shen L¹, Gu Y¹, Sun L, Yang Y, Wang F, Li Y, Bi S*. Development of a hepatitis delta virus antibody assay for study of the prevalence of HDV among individuals infected with hepatitis B virus in China. J Med Virol. 2012 Mar;84(3):445-9. (co-1st)

8. Tang X, Yang C, Gu Y, Song C, Zhang X, Wang Y, Zhang J, Hew CL, Li S*, Xia N*, Sivaraman J*. Structural basis for the neutralization and genotype specificity of hepatitis E virus. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10266-71.

9. Yu H, Li S*, Yang C, Wei M, Song C, Zheng Z, Gu Y, Du H, Zhang J, Xia N*. Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78. J Mol Model. 2011 May;17(5):987-95.

10. Zheng Z, Luo W*, Song H, Chen Y, Xiong J, Chen Y, Gu Y, Chen H, Shih JW, Zhang J, Xia N*. Antibody reactivity of conformational peptide mimics of a conserved H5N1 neutralization site in different fusion proteins. Arch Virol. 2010;155(1):19-26.

11. Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, Du H, Shih JW, Hew CL, Sivaraman J*, Xia N*. Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction. PLoS Pathog. 2009 Aug;5(8):e1000537.

12. Xu CY, Gu Y*, Hou WH, Que YQ, Gao SG, Cheng T, Xia NS*. Tetracysteine as a Reporter for Gene Therapy. Biomed Environ Sci. 2009 Dec;22(6):496-501.

13. Li S, Zhang J, He Z, Gu Y, Liu R, Lin J, Chen Y, Ng M, Xia N*. Mutational analysis of essential interactions involved in the assembly of hepatitis E virus capsid. J Biol Chem. 2005 Feb 4;280(5):3400-6.

14. Yang HJ, Chen M, Cheng T, He SZ, Li SW, Guan BQ, Zhu ZH, Gu Y, Zhang J, Xia NS. Expression and immunoactivity of chimeric particulate antigens of receptor binding site-core antigen of hepatitis B virus. World J Gastroenterol. 2005 Jan 28;11(4):492-7.

15. Zhang J, Gu Y, Ge SX, Li SW, He ZQ, Huang GY, Zhuang H, Ng MH, Xia NS. Analysis of hepatitis E virus neutralization sites using monoclonal antibodies directed against a virus capsid protein. Vaccine. 2005 Apr 22;23(22):2881-92.

16. Gu Y, Zhang J, Wang YB, Li SW, Yang HJ, Luo WX, Xia NS*. Selection of a peptide mimicking neutralization epitope of hepatitis E virus with phage peptide display technology. World J Gastroenterol. 2004 Jun 1;10 (11):1583-8.

17. Zhang J, Ge SX, Huang GY, Li SW, He ZQ, Wang YB, Zheng YJ, Gu Y, Ng MH, Xia NS. Evaluation of antibody-based and nucleic acid-based assays for diagnosis of hepatitis E virus infection in a rhesus monkey model. J Med Virol. 2003 Dec; 71(4): 518-26.